Anti-TPMT (Thiopurine S-methyltransferase, Thiopurine Methyltransferase)

Anti-TPMT (Thiopurine S-methyltransferase, Thiopurine Methyltransferase)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
134640.100 100 µg - -

3 - 19 business days*

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the... more
Product information "Anti-TPMT (Thiopurine S-methyltransferase, Thiopurine Methyltransferase)"
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq], Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1ug/ml, Immunofluorescence: 10ug/ml, Optimal dilutions to be determined by the researcher. AA Sequence: MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRRLEKVDAFEERHKSWGIDCLFEKLYLLTEK, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: 134640


Application: ELISA, IF, IHC, WB
Antibody Type: Monoclonal
Clone: 1B5
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Full length recombinant corresponding to aa1-245 from human TPMT (AAH05339) with GST tag. MW of the GST tag alone is 26kD.
Purity: Purified by Protein A affinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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