Anti-TPMT

Anti-TPMT
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*1 Offer expires 31/07/2021
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-60140.60 60 µl - -

7 - 16 business days*

117.00€
E-AB-60140.120 120 µl - -

7 - 16 business days*

208.00€
E-AB-60140.200 200 µl - -

7 - 16 business days*

363.00€
 
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the... more
Product information "Anti-TPMT"
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. Protein function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6- TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. [The UniProt Consortium]
Keywords: Anti-TPMT, Anti-Thiopurine methyltransferase, Anti-Thiopurine S-methyltransferase, TPMT Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-60140

Properties

Application: WB, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human TPMT

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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