Anti-TLR6 (Toll-like Receptor 6, CD286) (PE)

Anti-TLR6 (Toll-like Receptor 6, CD286) (PE)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T8050-53L.100 100 µg - -

3 - 19 business days*

719.00€
 
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins... more
Product information "Anti-TLR6 (Toll-like Receptor 6, CD286) (PE)"
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88:interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. the aa sequence of human TLR6 is most similar to hTLR1 with 69% identity at the aa level. Human TLR6 consists of a predicted 807aa with a molecular weight of approximately 92kD (3). Human and mouse TLR6 share an aa identity of 73%. TLR6 activates both NF-kB and c-Jun N-terminal Kinase (JNK). the aa in the cytoplasmic domain of IL-1 receptor, which are critical for NF-kB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6 (4). TLR6 is predominantly expressed in spleen, thymus, ovary, and lung (3). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry (Intracellular): 0.5-1ug/10e6 cells, Optimal dilutions to be determined by the researcher. Positive Control: Ramos, human PBMCs, Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Keywords: Anti-Toll-like receptor 6
Supplier: United States Biological
Supplier-Nr: T8050-53L

Properties

Application: FC
Antibody Type: Monoclonal
Clone: 11E375
Conjugate: Phycoerythrin
Host: Mouse
Species reactivity: human
Immunogen: Synthetic peptide corresponding to aa408-424 of human TRL6.
Format: Affinity Purified

Handling & Safety

Storage: +4°C (do not freeze)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-TLR6 (Toll-like Receptor 6, CD286) (PE)"
Write a review
or to review a product.
Viewed