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Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
*1
*1 Offer expires 30/06/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ABE-10-3026-NALE-100 | 100 µg | - |
3 - 11 business days* |
15 %
|
418.00€
355.30€ |
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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TLR2 (Toll-Like Receptors 2) is a member of the TLR (Toll-like receptor) family that plays a... more
Product information "Anti-TLR2 (Clone: ABM3A87)"
TLR2 (Toll-Like Receptors 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 also interacts with a large number of non-TLR molecules, allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial, and epithelial cells. Protein function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36), the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM. [The UniProt Consortium]
Keywords: | Anti-TIL4, Anti-TLR2, Anti-CD282, Anti-Toll-like receptor 2, Anti-Toll/interleukin-1 receptor-like protein 4, Monoclonal Antibody to TLR2 (Clone: ABM3A87) |
Supplier: | Abeomics |
Supplier-Nr: | 10-3026-NALE |
Properties
Application: | FC, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | ABM3A87 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | mouse, human |
Immunogen: | A partial length recombinant TLR2 protein (amino acids 180-420) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10159 | Matching products |
UniProt ID : | O60603 | Matching products |
Gene ID | GeneID 7097 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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