Anti-TIM3 (Hepatitis A Virus Cellular Receptor 2), Rabbit Monoclonal (RM448)

T cell Immunoglobulin and Mucin Domain-containing Molecule-3 (TIM-3) is present on T-helper type 1 lymphocytes and other immune cells including dendritic cells and natural killer cells. TIM-3 is overexpressed in CD4+ tumor-infiltrating lymphocytes, including those with non-small cell lung cancer associated with poor prognoses. The TIM gene family has an important role in the regulation of autoimmunity and allergies. TIM-3 has recently emerged as a potential target for cancer immunotherapy. Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. [The UniProt Consortium]