Anti-THOC5

Anti-THOC5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-119A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-119A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-119A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Acts as component of the THO subcomplex of the TREX complex which is thought to... more
Product information "Anti-THOC5"
Protein function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes. [The UniProt Consortium]
Keywords: Anti-THOC5, Anti-PP39.2, Anti-fSAP79, Anti-hTREX90, Anti-C22orf19, Anti-Placental protein 39.2, Anti-THO complex subunit 5 homolog, Anti-NF2/meningioma region protein pK1.3, Anti-Functional spliceosome-associated protein 79
Supplier: Bethyl Laboratories
Supplier-Nr: A302-119A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-119A-T maps to a region between residue 25 and 75 of human THO complex 5 using the numbering given in entry NP_003669.4 (GeneID 8563).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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