Anti-TERT

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-30259.20 20 µl - -

7 - 16 business days

63.00€
E-AB-30259.60 60 µl - -

7 - 16 business days

119.00€
E-AB-30259.120 120 µl - -

7 - 16 business days

211.00€
E-AB-30259.200 200 µl - -

7 - 16 business days

367.00€
 
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the... more
Product information "Anti-TERT"
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. [The UniProt Consortium]
Keywords: Anti-TP2, Anti-EST2, Anti-TERT, Anti-HEST2, EC=2.7.7.49, Anti-Telomerase catalytic subunit, Anti-Telomerase-associated protein 2, Anti-Telomerase reverse transcriptase, TERT Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-30259

Properties

Application: WB, IHC (paraffin), ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized peptide derived from the C-terminal region of human TERT.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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