Anti-Telomerase (hTERT Catalytic Unit)

Promotion:

Get a free Rockland T-Shirt with every Rockland purchase above 500 €.

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-252S 25 µl - -

1 - 9 business days

130.00€
600-401-252 100 µg - -

1 - 9 business days

471.00€
 
Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of... more
Product information "Anti-Telomerase (hTERT Catalytic Unit)"
Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. [The UniProt Consortium]
Keywords: Anti-TP2, Anti-TERT, Anti-EST2, Anti-HEST2, EC=2.7.7.49, Anti-Telomerase catalytic subunit, Anti-Telomerase-associated protein 2, Anti-Telomerase reverse transcriptase
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-252S

Properties

Application: WB, IP, IF, IHC
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human (Expected: Mouse (weak))
Immunogen: synthetic peptide corresponding to amino acids 1104-1123 of hTERT
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Telomerase (hTERT Catalytic Unit)"
16 May 2019

Best option on the market.

I had to use a little bit higher concentration than recommended but it works much better than any other anti-hTERT antibody I've tried!

Write a review
or to review a product.
Viewed