Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-64615.60 60 µl - -

7 - 16 business days*

E-AB-64615.120 120 µl - -

7 - 16 business days*

E-AB-64615.200 200 µl - -

7 - 16 business days*

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome... more
Product information "Anti-TARDBP"
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. Protein function: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. [The UniProt Consortium]
Keywords: Anti-TDP43, Anti-TARDBP, Anti-TDP-43, Anti-TAR DNA-binding protein 43, TARDBP Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-64615


Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human TARDBP

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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