Anti-TAR DNA Binding Protein 43 (TARDBP, TDP-43, TDP43)

Anti-TAR DNA Binding Protein 43 (TARDBP, TDP-43, TDP43)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T1019-47A.100 100 µl - -

3 - 19 business days*

498.00€
 
HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that... more
Product information "Anti-TAR DNA Binding Protein 43 (TARDBP, TDP-43, TDP43)"
HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression, by the transactivator Tat, is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. Recently it has been shown that TDP-43 accumulates abnormally in post-mortem brain tissue from individuals diagnosed with both ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This observation provides a long sought connection between two disease that often over-lap clinically. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml, Immunofluorescence (IC): 1:100-1:1000. A nuclear signal is present in MCF-7 cells., Optimal dilutions to be determined by the researcher. Positive Control: Hela Whole Cell Extract, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-TDP43, Anti-TARDBP, Anti-TDP-43, Anti-TAR DNA-binding protein 43
Supplier: United States Biological
Supplier-Nr: T1019-47A

Properties

Application: ICC, IF, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Chicken, Human, Monkey, Mouse, Xenopus
Immunogen: A synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein. [Swiss-Prot# Q13148]. Homology: 100% with human, monkey, mouse, chicken, Xenopus, and Zebrafish.
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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