Anti-TAB1 (Ser423) (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, TGF-beta-activated Kin

Anti-TAB1 (Ser423) (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, TGF-beta-activated Kin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T0291-85K-Biotin.200 200 µl - -

3 - 19 business days*

993.00€
 
MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is... more
Product information "Anti-TAB1 (Ser423) (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, TGF-beta-activated Kin"
MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-1:500, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-TAB1, Anti-MAP3K7IP1, Anti-TAK1-binding protein 1, Anti-TGF-beta-activated kinase 1-binding protein 1, Anti-TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Anti-Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
Supplier: United States Biological
Supplier-Nr: T0291-85K-Biotin

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide selected from the amino acid residues surrounding S423 of human MAP3K7IP1 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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