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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-N1087-25UG | 25 µg | - | - |
3 - 10 business days* |
317.00€
|
||
NSJ-N1087-100UG | 100 µg | - | - |
3 - 10 business days* |
622.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Survivin, also called BIRC5, is a... more
Product information "Anti-Survivin"
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level. Protein function: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. [The UniProt Consortium]
Keywords: | Anti-API4, Anti-BIRC5, Anti-Apoptosis inhibitor 4, Anti-Apoptosis inhibitor survivin, Anti-Baculoviral IAP repeat-containing protein 5, Survivin Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | N1087 |
Properties
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A recombinant protein fragment from human Survivin was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K08731 | Matching products |
UniProt ID : | O15392 | Matching products |
Gene ID | GeneID 332 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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