Anti-SUMO2/3

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F42562-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F42562-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Covalent modification of target lysines by SUMO... more
Product information "Anti-SUMO2/3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1. Protein function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). [The UniProt Consortium]
Keywords: Anti-Smt3A, Anti-SUMO-2, Anti-SUMO-3, Anti-SMT3 homolog 1, Anti-Ubiquitin-like protein SMT3A, Anti-Small ubiquitin-related modifier 3, SUMO2/3 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F42562

Properties

Application: IF, WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat
Immunogen: This SUMO2/3 antibody recognizes SUMO2 and SUMO3. It was produced from rabbits immunized with a recombinant protein encoding full length human SUMO3.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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