Anti-STUB1/CHIP

Anti-STUB1/CHIP
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-573A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-573A 100 µl (100 µg) -

3 - 9 business days

430.00€
 
Protein function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates... more
Product information "Anti-STUB1/CHIP"
Protein function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin- mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). [The UniProt Consortium]
Keywords: Anti-Antigen NY-CO-7, Anti-CLL-associated antigen KW-8, Anti-E3 ubiquitin-protein ligase CHIP, Anti-RING-type E3 ubiquitin transferase CHIP, Anti-STIP1 homology and U box-containing protein 1, Anti-Carboxy terminus of Hsp70-interacting protein
Supplier: Bethyl Laboratories
Supplier-Nr: A301-573A-T

Properties

Application: IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Chicken)
Immunogen: synthetic peptide. The epitope recognized by A301-573A-T maps to a region between residue 253 and 303 of human STIP1 homology and U-box containing protein 1 (carboxy terminus of Hsp70-interacting protein) using the numbering given in entry NP_005852.2 (GeneID 10273).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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