Anti-SPP

Anti-SPP
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-404A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-404A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-404A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Catalyzes intramembrane proteolysis of some signal peptides after they have... more
Product information "Anti-SPP"
Protein function: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection. [The UniProt Consortium]
Keywords: Anti-H13, Anti-HM13, Anti-hIMP1, Anti-IMP-1, Anti-MSTP086, Anti-IMPAS-1, EC=3.4.23.-, Anti-Signal peptide peptidase, Anti-Intramembrane protease 1, Anti-Presenilin-like protein 3, Anti-Minor histocompatibility antigen H13
Supplier: Bethyl Laboratories
Supplier-Nr: A304-404A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Dog, Horse, Rabbit, Guinea Pig_10141, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Cat, Crab-eating Macaque, European Domestic Ferret, Northern White-cheeked Gibbon, Small-eared Galago)
Immunogen: synthetic peptide. The epitope recognized by A304-404A-T maps to a region between residue 327 to 377 of human Signal Peptide Peptidase Like 1 using the numbering given in entry NP_110416.1 (GeneID 81502).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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