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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
S5451-08C.100 | 100 µg | - | - |
3 - 19 business days* |
688.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Sphingosine 1-phosphate receptor Edg8 is a multi-pass membrane protein belonging to the G-protein... more
Product information "Anti-Sphingolipid Receptor (Edg8/S1P5, Endothelial Differentiation G-protein-coupled Receptor 8, EDG"
Sphingosine 1-phosphate receptor Edg8 is a multi-pass membrane protein belonging to the G-protein coupled receptor 1 family and coupled to both the G (i:0) alpha and G (12) subclass of heteromeric G-proteins. Edg8 acts as a receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) as well as for lysolipid mediator lysophosphatidic acid (LPA) and gives diverse physiological effect on most types of cells and tissues. Edg8 may also play a regulatory role in the transformation of radial glial cells into astrocytes and affect proliferative activity of these cells. It is widely expressed in white matter tracts of brain, spleen, peripheral blood leukocytes, placenta, lung, aorta, and fetal spleen. Over expression of Edg8 leads to a lymphoproliferative disorder often associated with the autoimmune disease known as leukemic large granular lymphocyte (LGL). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml, Immunohistochemistry (paraffin): 5-10ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human, mouse and rat brain lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-S1P receptor 5, Anti-S1P receptor Edg-8, Anti-Sphingosine 1-phosphate receptor 5, Anti-Sphingosine 1-phosphate receptor Edg-8, Anti-Endothelial differentiation G-protein-coupled receptor 8 |
Supplier: | United States Biological |
Supplier-Nr: | S5451-08C |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | dog, human, monkey, mouse, rat |
Immunogen: | Synthetic peptide corresponding to aa1-50 of human Edg8. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04295 | Matching products |
UniProt ID : | Q9H228 | Matching products |
Gene ID | GeneID 53637 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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