Anti-SOX10(Melanoma Marker) Recombinant Rabbit Monoclonal Antibody (clone:SOX10/2311R)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-12-1244-100 100 µg -

3 - 11 business days*

850.00€
 
SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY.... more
Product information "Anti-SOX10(Melanoma Marker) Recombinant Rabbit Monoclonal Antibody (clone:SOX10/2311R)"
SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas.In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells. Protein function: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). [The UniProt Consortium]
Keywords: Anti-SOX10, Anti-Transcription factor SOX-10, Anti-SOX10(Melanoma Marker) Recombinant Rabbit Monoclonal Antibody (Clone:SOX10/2311R)
Supplier: Abeomics
Supplier-Nr: 12-1244

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: SOX10/2311R
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Recombinant fragment of human SOX10 protein (around aa 115-269) (exact sequence is proprietary)
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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