Anti-SOX10, clone SOX10/992

Anti-SOX10, clone SOX10/992
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2867SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a protein of ~55kDa, identified... more
Product information "Anti-SOX10, clone SOX10/992"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a protein of ~55kDa, identified as SOX10. This mAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells. Protein function: Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia. [The UniProt Consortium]
Keywords: Anti-SOX10, Anti-Transcription factor SOX-10, SOX10 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2867SAF-100UG

Properties

Application: FC, IF, WB
Antibody Type: Monoclonal
Clone: SOX10/992
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A partial recombinant protein (aa 115-269) from human SOX10
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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