Anti-SODD (Silencer of Death Domains, BCL2-associated Athanogene 4, BAG4)

Anti-SODD (Silencer of Death Domains, BCL2-associated Athanogene 4, BAG4)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S2000-32.50 50 µg - -

1 - 19 business days

650.00€
 
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through... more
Product information "Anti-SODD (Silencer of Death Domains, BCL2-associated Athanogene 4, BAG4)"
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-BAG-4, Anti-Silencer of death domains, Anti-Bcl-2-associated athanogene 4, Anti-BAG family molecular chaperone regulator 4
Supplier: United States Biological
Supplier-Nr: S2000-32

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: peptide corresponding to amino acids near the amino terminus of human SODD
Format: Highly Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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