Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-535A 100 µl (100 µg) -

3 - 9 business days

Protein function: Serine/threonine protein kinase involved in both mRNA surveillance and... more
Product information "Anti-SMG1"
Protein function: Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. [The UniProt Consortium]
Keywords: Anti-ATX, Anti-SMG1, Anti-SMG-1, Anti-hSMG-1, Anti-61E3.4, EC=, Anti-Lambda-interacting protein, Anti-Serine/threonine-protein kinase SMG1, Anti-Lambda/iota protein kinase C-interacting protein
Supplier: Bethyl Laboratories
Supplier-Nr: A301-535A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A301-535A maps to a region between residue 1250 and 1300 of human PI-3-Kinase-related kinase SMG1 using the numbering given in entry NP_055907.3 (GeneID 23049).
Format: Antigen Affinity Purified

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Our products are for laboratory research use only: Not for administration to humans!
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