Anti-SIRT 6 (Sirtuin 5, Sir2-like Protein Type 6)

Anti-SIRT 6 (Sirtuin 5, Sir2-like Protein Type 6)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S1013-88K.100 100 µl - -

4 - 22 business days

496.00€
 
The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that... more
Product information "Anti-SIRT 6 (Sirtuin 5, Sir2-like Protein Type 6)"
The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as Class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Pol-beta or other core components of the pathway. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunofluorescence: (IF-IC) 1:100, Western Blot: 1:1000, Immunoprecipitation: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: S1013-88K

Properties

Application: IF, IP, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide (KLH-coupled) corresponding to the carboxy terminus of the human SirT6 protein.

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-SIRT 6 (Sirtuin 5, Sir2-like Protein Type 6)"
Write a review
or to review a product.
Viewed