Anti-SHARPIN

Anti-SHARPIN
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-559A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A303-559A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in... more
Product information "Anti-SHARPIN"
Protein function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. [The UniProt Consortium]
Keywords: Anti-SIPL1, Anti-hSIPL1, Anti-Sharpin, Anti-SHARPIN, Anti-PSEC0216, Anti-Shank-interacting protein-like 1, Anti-Shank-associated RH domain-interacting protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-559A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: bovine)
Immunogen: synthetic peptide. The epitope recognized by A303-559A-T maps to a region between residue 25 and 75 of human Shank-Associated RH Domain-Interacting Protein using the numbering given in entry NP_112236.3 (GeneID 81858).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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