Anti-SF3B2

Anti-SF3B2
Promotion:

For a limited time, purchase an Elabscience primary antibody (size 60 μl and up) and receive a free secondary antibody of the same size.

*1
*1 Offer expires 30/04/2020
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-61816.60 60 µl - -

7 - 16 business days

119.00€
E-AB-61816.120 120 µl - -

7 - 16 business days

211.00€
E-AB-61816.200 200 µl - -

7 - 16 business days

367.00€
 
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b,... more
Product information "Anti-SF3B2"
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. Protein function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). [The UniProt Consortium]
Keywords: Anti-SF3B2, Anti-SAP145, Anti-SF3b145, Anti-SAP 145, Anti-Splicing factor 3B subunit 2, Anti-Spliceosome-associated protein 145, Anti-Pre-mRNA-splicing factor SF3b 145 kDa subunit, SF3B2 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-61816-60µL

Properties

Application: WB, IHC, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SF3B2

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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