Anti-SARS-CoV-2 Whole Spike Protein

Anti-SARS-CoV-2 Whole Spike Protein
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-MS9 100 µg - -

6 - 10 business days*

684.00€
 
Anti-SARS-CoV-2 Spike antibody is directed against SARS Coronavirus 2 Spike protein. The product... more
Product information "Anti-SARS-CoV-2 Whole Spike Protein"
Anti-SARS-CoV-2 Spike antibody is directed against SARS Coronavirus 2 Spike protein. The product was purified from monospecific antiserum by immunoaffinity chromatography. BLAST analysis was used to suggest reactivity with related Coronavirus proteins.  Cross reactivity with homologues from other sources has not been determined. Protein function: [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell (PubMed:33082294, PubMed:33082293). This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2 (PubMed:33082293). The stalk domain of S contains three hinges, giving the head unexpected orientational freedom (PubMed:32817270). Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Can be alternatively processed by host furin (PubMed:32362314). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. [The UniProt Consortium]
Keywords: Anti-2, SARS-CoV-2 Whole Spike Protein Antibody
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-MS9

Properties

Application: ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: SARS-CoV-2
Immunogen: purified SARS-CoV-2 S protein with His-tag, derived from the transfected human HEK293 cells.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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