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Protein function: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. [The UniProt Consortium]
synthetic peptide. The epitope recognized by A303-768A-T maps to a region between residue 1 and 50 of human Smad Anchor for Receptor Activation using the numbering given in entry NP_004790.2 (GeneID 9372).
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