Anti-SAM68

Anti-SAM68
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-110A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-110A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-110A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Recruited and tyrosine phosphorylated by several receptor systems, for example... more
Product information "Anti-SAM68"
Protein function: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4. [The UniProt Consortium]
Keywords: Anti-p68, Anti-Sam68, Anti-Src-associated in mitosis 68 kDa protein, Anti-GAP-associated tyrosine phosphoprotein p62, Anti-p21 Ras GTPase-activating protein-associated p62, Anti-KH domain-containing, RNA-binding, signal transduction-associated protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-110A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rabbit, Guinea Pig_10141, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Small-eared Galago)
Immunogen: synthetic peptide. The epitope recognized by A302-110A-T maps to a region between residue 1 and 50 of human Src-associated in mitosis 68 kDa protein (KH domain containing, RNA binding, signal transduction associated 1) using the numbering given in entry NP_006550.1 (GeneID 10657).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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