Anti-S100B, clone S100B/1706R (recombinant antibody)

Anti-S100B, clone S100B/1706R (recombinant antibody)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3350-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3350-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. S100 belongs to the... more
Product information "Anti-S100B, clone S100B/1706R (recombinant antibody)"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein. Protein function: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. [The UniProt Consortium]
Keywords: Anti-S100B, Anti-Protein S100-B, Anti-S-100 protein beta chain, Anti-S-100 protein subunit beta, Anti-S100 calcium-binding protein B, Recombinant S100B Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3350-20UG

Properties

Application: FC, IF, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: S100B/1706R
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat, Bovine
Immunogen: Full length human recombinant S100B protein was used as the immunogen for this recombinant S100B antibody.
Format: Purified

Database Information

UniProt ID : P04271 | Find alternatives
Gene ID GeneID 6285 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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