Anti-Rtf1 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00272-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00272 100 µl (50+ slides) -

3 - 9 business days

456.00€
 
Protein function: Component of the PAF1 complex (PAF1C) which has multiple functions during... more
Product information "Anti-Rtf1 (IHC)"
Protein function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency, this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex. [The UniProt Consortium]
Keywords: Anti-RTF1, Anti-KIAA0252, Anti-RNA polymerase-associated protein RTF1 homolog
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00272-T

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Zebrafish, X. Tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Medaka Fish, Nile Tilapia, Spotted Green Pufferfish)
Immunogen: synthetic peptide. The epitope recognized by IHC-00272 maps to the C-terminus of human Restores TBP (TATA box-binding protein) Function-1 using the numbering given in entry EAW92492.1 (GeneID 23168).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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