Anti-RRP8

Anti-RRP8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-201A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-201A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-201A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Essential component of the eNoSC (energy-dependent nucleolar silencing)... more
Product information "Anti-RRP8"
Protein function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. [The UniProt Consortium]
Keywords: Anti-RRP8, Anti-hucep-1, Anti-KIAA0409, EC=2.1.1.-, Anti-Nucleomethylin, Anti-Cerebral protein 1, Anti-Ribosomal RNA-processing protein 8
Supplier: Bethyl Laboratories
Supplier-Nr: A304-201A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Horse, Rabbit, Guinea Pig_10141, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Cetartiodactyla, Wild Yak, White-tufted-ear Marmoset, Cat, Naked Mole Rat, Crab-eating Macaque, Thirteen-lined Ground Squirrel)
Immunogen: synthetic peptide. The epitope recognized by A304-201A-T maps to a region between residue 1 to 50 of human Ribosomal RNA Processing 8 using the numbering given in entry NP_056139.1 (GeneID 23378).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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