Anti-Rps6kb1, CT (Rps6kb1, Ribosomal protein S6 kinase beta-1, 70kD ribosomal protein S6 kinase 1, R

Anti-Rps6kb1, CT (Rps6kb1, Ribosomal protein S6 kinase beta-1, 70kD ribosomal protein S6 kinase 1, R
Item number Size Datasheet Manual SDS Delivery time Quantity Price
041260.200 200 µl - -

1 - 19 business days

557.00€
 
Rps6kb1 acts to integrate nutrient and growth factor signals in regulation of protein synthesis,... more
Product information "Anti-Rps6kb1, CT (Rps6kb1, Ribosomal protein S6 kinase beta-1, 70kD ribosomal protein S6 kinase 1, R"
Rps6kb1 acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling, probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance, probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-136' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex, probably phosphorylates RMP at 'Ser-136'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates POLDIP3 (By similarity). Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-S6K, Anti-S6K1, Anti-P70S6K1, Anti-Rps6kb1, Anti-p70 S6KA, Anti-p70-S6K 1, Anti-S6K-beta-1, EC=2.7.11.1, Anti-p70 S6K-alpha, Anti-p70 S6 kinase alpha, Anti-Ribosomal protein S6 kinase I, Anti-p70 ribosomal S6 kinase alpha
Supplier: United States Biological
Supplier-Nr: 041260

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Mouse Rps6kb1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of Mouse Rps6kb1.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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