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This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the... more
Product information "Anti-RPGR"
This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. Protein function: Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. May be involved in microtubule organization and regulation of transport in primary cilia. [The UniProt Consortium]
Keywords: | Anti-RP3, Anti-RPGR, Anti-X-linked retinitis pigmentosa GTPase regulator, RPGR Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-60472 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant protein of human RPGR |
Database Information
KEGG ID : | K19607 | Matching products |
UniProt ID : | Q92834 | Matching products |
Gene ID | GeneID 6103 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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