Anti-Roquin

Anti-Roquin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-514A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-514A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif,... more
Product information "Anti-Roquin"
Protein function: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS- stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. [The UniProt Consortium]
Keywords: Anti-RC3H1, Anti-Roquin, Anti-KIAA2025, Anti-Roquin-1, Anti-RING finger protein 198, Anti-RING finger and C3H zinc finger protein 1, Anti-RING finger and CCCH-type zinc finger domain-containing protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A300-514A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: horse, swine, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, chinese hamster, naked mole rat, thirteen-lined ground squirrel, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-514A-T maps to a region between residues 500 and 550 of human Ring Finger and CCCH-type finder domains 1 using the numbering given in entry NP_742068.1 (GeneID 149041).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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