Anti-RNF144B

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-15118.20 20 µl -

7 - 16 business days*

71.00€
E-AB-15118.60 60 µl -

7 - 16 business days*

143.00€
E-AB-15118.120 120 µl -

7 - 16 business days*

238.00€
E-AB-15118.200 200 µl -

7 - 16 business days*

396.00€
 
p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads... more
Product information "Anti-RNF144B"
p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle. Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death, But, it is not an anti-apoptotic protein per se. [The UniProt Consortium]
Keywords: Anti-IBRDC2, Anti-RNF144B, Anti-RING finger protein 144B, Anti-IBR domain-containing protein 2, Anti-p53-inducible RING finger protein, Anti-E3 ubiquitin-protein ligase RNF144B, RNF144B Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-15118

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Recombinant protein of human RNF144B
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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