Anti-Rnasel, NT (Rnasel, Rns4, 2-5A-dependent ribonuclease, Ribonuclease 4, Ribonuclease L)

Anti-Rnasel, NT (Rnasel, Rns4, 2-5A-dependent ribonuclease, Ribonuclease 4, Ribonuclease L)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
041100.200 200 µl - -

1 - 19 business days

557.00€
 
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and... more
Product information "Anti-Rnasel, NT (Rnasel, Rns4, 2-5A-dependent ribonuclease, Ribonuclease 4, Ribonuclease L)"
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity). Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Rns4, Anti-Rnasel, Anti-RNase L, EC=3.1.26.-, Anti-Ribonuclease L, Anti-Ribonuclease 4, Anti-2-5A-dependent RNase, Anti-2-5A-dependent ribonuclease
Supplier: United States Biological
Supplier-Nr: 041100

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-167 amino acids from the N-terminal region of Mouse Rnasel.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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