Anti-RIP

Anti-RIP
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-20-1083 50 µl -

2 - 11 business days

319.00€
ABE-20-1083-50 50 µl -

2 - 11 business days

319.00€
 
RIP (Receptor Interacting Protein) is a 74 ka Ser/Thr kinase which interacts with CD95 (Fas/APO1)... more
Product information "Anti-RIP"
RIP (Receptor Interacting Protein) is a 74 ka Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD, TRADD, and RIP in their signal transduction pathways. RIP deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues. Protein function: Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. [The UniProt Consortium]
Keywords: Anti-HRB, Anti-AGFG1, Anti-Rev-interacting protein, Anti-HIV-1 Rev-binding protein, Anti-Nucleoporin-like protein RIP, Anti-Rev/Rex activation domain-binding protein, Anti-Arf-GAP domain and FG repeat-containing protein 1, Polyclonal antibody to RIP
Supplier: Abeomics
Supplier-Nr: 20-1083

Properties

Application: IP, IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: A synthetic peptide of human RIP1 (amino acids 269-287 EANPEARPTFPGIEEKFRP) was used as immunogen for this antibody
Format: Sera

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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