Anti-Ricin communis, B chain (RCA I, Castor bean)

Anti-Ricin communis, B chain (RCA I, Castor bean)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
R2031-52J.200 200 µg - -

3 - 19 business days

598.00€
 
The ricin toxin consists of two chains, A and B, covalently linked by a disulfide bond. The A... more
Product information "Anti-Ricin communis, B chain (RCA I, Castor bean)"
The ricin toxin consists of two chains, A and B, covalently linked by a disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essential for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from the castor bean (Ricinus communis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, although a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for biological warfare although it is less stable than other agents, such as anthrax. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Optimal dilution to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=3.2.2.22, Anti-Ricin B chain, Anti-Ricin A chain, Anti-Linker peptide, Anti-rRNA N-glycosidase
Supplier: United States Biological
Supplier-Nr: R2031-52J

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 9A200
Conjugate: No
Host: Mouse
Purity: Purified by Protein G affinity chromatography.
Format: Affinity Purified

Database Information

UniProt ID : P02879 | Find alternatives
Gene ID GeneID 8287993 | Find alternatives

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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