Anti-RFX5

Anti-RFX5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-61439.60 60 µl - -

7 - 16 business days*

149.00€
E-AB-61439.120 120 µl - -

7 - 16 business days*

262.00€
E-AB-61439.200 200 µl - -

7 - 16 business days*

459.00€
 
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II... more
Product information "Anti-RFX5"
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS, MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. Protein function: Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. [The UniProt Consortium]
Keywords: Anti-RFX5, Anti-Regulatory factor X 5, Anti-DNA-binding protein RFX5, RFX5 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-61439

Properties

Application: IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant protein of human RFX5

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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