Anti-RBM8A

Anti-RBM8A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-CAB15125.100 100 µl -

9 - 20 business days

299.00€
 
WB 1:500 - 1:2000. Protein function: Core component of the splicing-dependent multiprotein exon... more
Product information "Anti-RBM8A"
WB 1:500 - 1:2000. Protein function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly. [The UniProt Consortium]
Keywords: Anti-RBM8, Anti-RBM8A, Anti-BOV-1, Anti-HSPC114, Anti-Binder of OVCA1-1, Anti-RNA-binding protein 8A, Anti-Ribonucleoprotein RBM8A, Anti-RNA-binding protein Y14, Anti-RNA-binding motif protein 8A, RBM8A Polyclonal Antibody (CAB15125)
Supplier: Antibody Genie
Supplier-Nr: CAB15125

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human RBM8A (NP_005096.1).
MW: 20 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-RBM8A"
Write a review
or to review a product.
Viewed