Anti-RasGRP2, pAb (IG-09)

Anti-RasGRP2, pAb (IG-09)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-25T-0118-R100 100 µl -

3 - 9 business days*

10 %
418.00€
376.20€
 
RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically... more
Product information "Anti-RasGRP2, pAb (IG-09)"
RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets. In vitro, ERK1/2 phosphorylates RasGRP2 at Ser394 to limit its exchange activity and inhibits its ability to activate the small GTPase Rap1 that ultimately leads to decreased activation of ERK1/2 in cells.
Keywords: Anti-CDC25L, Anti-hCDC25L, Anti-RASGRP2, Anti-CalDAG-GEFI, Anti-Cdc25-like protein, Anti-F25B3.3 kinase-like protein, Anti-RAS guanyl-releasing protein 2, Anti-Calcium and DAG-regulated guanine nucleotide exchange factor I
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-25T-0118

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Synthetic peptide corresponding to a human RasGRP2 sequence located at the C-terminus of the RasGEF domain.
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-RasGRP2, pAb (IG-09)"
Write a review
or to review a product.
Viewed