Anti-RAD51C

Anti-RAD51C
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-645A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-645A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-645A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved... more
Product information "Anti-RAD51C"
Protein function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment, CX3 seems to act downstream of RAD51 recruitment, both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process, the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. [The UniProt Consortium]
Keywords: Anti-R51H3, Anti-RAD51C, Anti-RAD51L2, Anti-RAD51 homolog C, Anti-RAD51-like protein 2, Anti-DNA repair protein RAD51 homolog 3
Supplier: Bethyl Laboratories
Supplier-Nr: A302-645A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-645A-T maps to a region between residue 326 and 376 of human RAD51 homolog C using the numbering given in entry NP_478123.1 (GeneID 5889).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-RAD51C"
Write a review
or to review a product.
Viewed