Anti-Rad50, CT (Rad50, DNA repair protein RAD50)

Anti-Rad50, CT (Rad50, DNA repair protein RAD50)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
040797.200 200 µl - -

1 - 19 business days

557.00€
 
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA... more
Product information "Anti-Rad50, CT (Rad50, DNA repair protein RAD50)"
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity). Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Rad50, Anti-mRad50, EC=3.6.-.-, Anti-DNA repair protein RAD50
Supplier: United States Biological
Supplier-Nr: 040797

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: Mouse Rad50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 910-938 amino acids from the C-terminal region of mouse Rad50.
Format: Affinity Purified

Database Information

UniProt ID : P70388 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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