Anti-PUF60

Anti-PUF60
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-817A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-817A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-817A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: DNA- and RNA-binding protein, involved in several nuclear processes such as... more
Product information "Anti-PUF60"
Protein function: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA, binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA. [The UniProt Consortium]
Keywords: Anti-FIR, Anti-PUF60, Anti-RoBP1, Anti-Siah-BP1, Anti-Ro-binding protein 1, Anti-Siah-binding protein 1, Anti-FBP-interacting repressor, Anti-Poly(U)-binding-splicing factor PUF60, Anti-60 kDa poly(U)-binding-splicing factor
Supplier: Bethyl Laboratories
Supplier-Nr: A302-817A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-817A-T maps to a region between residue 1 and 50 of human Poly-U Binding Splicing Factor 60KDa using the numbering given in entry NP_510965.1 (GeneID 22827).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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