Anti-PTGDS (Lipocalin-type prostaglandin-D synthase, L-PGDS, Glutathione-independent PGD synthetase,

Anti-PTGDS (Lipocalin-type prostaglandin-D synthase, L-PGDS, Glutathione-independent PGD synthetase,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P9053-24D.100 100 µl - -

4 - 22 business days

498.00€
 
Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in... more
Product information "Anti-PTGDS (Lipocalin-type prostaglandin-D synthase, L-PGDS, Glutathione-independent PGD synthetase,"
Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in CSF and it induces neuronal cell protection and neuronal cell loss, depending on the receptor pathway it signals to the target cells. L-PGDS is found secreted as well as localized to RER, nuclear membrane, Golgi apparatus, perinuclear cytoplasm etc and has been detected in arachnoid and menigioma cells, arachnoid trabecular cells, meningeal macrophages and perivascular microglial cells, oligodendrocytes as well as RPE cells. L-PGDS catalyzes the metabolic transformation of PGH2 to PGD2, a prostaglandin implicated in smooth muscle contraction/relaxation and a platelet aggregation inhibitor. It is implicated in several CNS functions including sedation, NREM sleep and PGE2-induced allodynia, and plays anti-apoptotic role in oligodendrocytes. L-PGDS can bind to small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. L-PGDS has also been suggested to play role in development and maintenance of blood-brain, blood-retina, blood-aqueous humor and blood-testis barriers. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilutions: Western Blot: 2ug/ml , Optimal dilutions to be determined by the researcher. Positive Control: Human brain lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-PDS, EC=5.3.99.2, Anti-Prostaglandin-H2 D-isomerase, Anti-Glutathione-independent PGD synthase
Supplier: United States Biological
Supplier-Nr: P9053-24D

Properties

Application: WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Bovine, Dog, Cat, Human, Monkey, Mouse, Rabbit, Rat (Expected: Bovine, Dog, Cat, Human, Monkey, Mouse, Rabbit, Rat)
Immunogen: Synthetic peptide corresponding to a region between aa120 and 190. The epitope recognized by this antibody maps to region within residue 120-190 of human PTGDS. [Swiss-Prot# P41222]
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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