Anti-PSMD10

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-60519.60 60 µl - -

7 - 16 business days*

117.00€
E-AB-60519.120 120 µl - -

7 - 16 business days*

208.00€
E-AB-60519.200 200 µl - -

7 - 16 business days*

363.00€
 
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the... more
Product information "Anti-PSMD10"
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. Protein function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. [The UniProt Consortium]
Keywords: Anti-PSMD10, Anti-Gankyrin, Anti-p28(GANK), Anti-26S proteasome regulatory subunit p28, Anti-26S proteasome non-ATPase regulatory subunit 10, PSMD10 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-60519

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human PSMD10

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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