Anti-Protor-1

Anti-Protor-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-188A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-188A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-188A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to... more
Product information "Anti-Protor-1"
Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. [The UniProt Consortium]
Keywords: Anti-PRR5, Anti-PP610, Anti-PROTOR1, Anti-Protor-1, Anti-Proline-rich protein 5, Anti-Protein observed with Rictor-1
Supplier: Bethyl Laboratories
Supplier-Nr: A304-188A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A304-188A-T maps to a region between residue 338 to 388 of human Protein Observed with Rictor-1 using the numbering given in entry NP_851850.1 (GeneID 55615).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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Offer
Anti-PRR5 Anti-PRR5
506.00€ *
Anti-PRR5 Anti-PRR5
From 63.00€ *
Anti-Protor-1 Anti-Protor-1
From 131.00€ *
Anti-PRR5 Anti-PRR5
314.00€ *
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