Anti-Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase (PRKR, EC 2.7

Anti-Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase (PRKR, EC 2.7
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P9104-93.50 50 µg - -

4 - 22 business days

650.00€
 
EIF-2alpha, also known as eukaryotic translation initiation factor 2alpha, promotes the binding... more
Product information "Anti-Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase (PRKR, EC 2.7"
EIF-2alpha, also known as eukaryotic translation initiation factor 2alpha, promotes the binding of the initiator tRNA to the 40S ribosomal subunits and controls translational rates via phosphorylation/dephosphorylation mechanisms. The double-stranded RNA (dsRNA)-activated protein kinase (PKR) provides an important control in the regulation of protein synthesis initiation through the phosphorylation of eIF-2alpha. Phosphorylated eIF-2 alpha inhibits cell growth and induces apoptosis. Phosphorylation of eIF-2alpha occurs under a variety of conditions including viral infection, apoptosis, nutrient deprivation, heme-deprivation, and certain stresses. EIF-2 exists as a heterotrimeric protein composed of 3 nonidentical subunits, alpha (36kD), beta (38kD), and gamma (52kD)., , Applications: , Suitable for use in ELISA, Western Blotting, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blotting: 1:1000-1:2000, Immunohistochemistry: 2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-PKR, EC=2.7.11.1, EC=2.7.10.2, Anti-p68 kinase, Anti-eIF-2A protein kinase 2, Anti-P1/eIF-2A protein kinase, Anti-Protein kinase RNA-activated, Anti-Tyrosine-protein kinase EIF2AK2, Anti-Interferon-inducible RNA-dependent protein kinase
Supplier: United States Biological
Supplier-Nr: P9104-93

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: peptide corresponding to 14 amino acids near the carboxy terminus of human PKR

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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