Anti-Prostaglandin Transporter (C-Term)

Prostaglandins (PGs) are signaling molecules that modulate physiological or pathologic functions such as platelet aggregation, vascular tone, gastric cytoprotection, uterine contraction, inflammation, cancer and Alzheimer's disease. PG transporter (PGT) is generally expressed in endothelial and epithelial cells. Transport of extracellular PGs into cells occurs via a specific PGT, allowing PG oxidation by 15-hydroxy PG dehydrogenase or binding with their respective receptor(s). Cayman's peptide-affinity purified PGT polyclonal antibody detects a 71 kDa band on WB. Loss of PGT detection may occur due to cell membrane aggregation during exposure of some samples to high temperature processing. Therefore treatment of the protein sample at 37°C for 15 minutes (water bath or heating block), and if desired, in parallel with another aliquot at 95°C is recommended prior to electrophoresis and blotting. When using the antibody for ICC or IF, cell permeabilization is necessary due to the intracellular location of the antibody binding site (C-terminal amino acids).Synonyms: OATP2A1, PGT, SLCO2A1, Solute carrier organic anion transporter family member 2A1. Immunogen: A synthetic peptide from the C-terminal region of human PGT. Formulation: (Request formulation change), 500 µl of peptide affinity purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: WB. UniProt Accession #: Q92959. Origin: Animal/Rabbit.