Anti-Prostaglandin I Synthase (Clone 3C8)

Prostaglandin I synthase (PGIS) catalyzes the isomerization of PGH2 to PGI2. PGI2 (prostacyclin) is a potent vasodilator and inhibitor of platelet aggregation. PGIS is a membrane-bound hemoprotein localized primarily in endothelial cells. The cloned bovine and human enzymes contain 500 amino acids and a calculated molecular mass of 56,629 and 57,103, respectively. Northern blot analysis reveals that the mRNA for PGIS is expressed in a wide variety of human tissues and is particularly abundant in ovary, heart, skeletal muscle, lung, and prostate.Synonyms: PGIS, Prostacyclin Synthase. Immunogen: Cell surface PGIS from follicular dendritic cell line HK. Clone Designation: 3C8. Formulation: (Request formulation change), 200 µg of lyophilized protein G-purified monoclonal antibody. Storage Buffer: TBS, pH 7.4 when resuspended in 500 µl double distilled water. Host: Mouse. Applications: FC, ICC, IHC, IP, WB. License: Sold under license from Kangwon National University. UniProt Accession #: Q16647. Origin: Animal/Mouse.