Anti-Prostaglandin E Synthase-1 (microsomal)

Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 (Cay-17020) to PGE2 (Cay-14010). PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. PGES-1 is a 16 kDa membrane-associated protein with glutathione-dependent activity. The mRNA is for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells. PGES-1 protein expression is increased in A549 cells following treatment with IL-1betaSynonyms: Membrane-Associated PGES-1, MGST1-L1, mPGES-1, mPGE Synthase-1, PIG12, Prostaglandin H/E Isomerase. Immunogen: Peptide from an internal region of human mPGES-1. Formulation: (Request formulation change), 500 µl of Peptide-affinity purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: Immunofluorescence (IF), Western blot (WB). Cross Reactivity: (-) cPGES. UniProt Accession #: O14684. Origin: Animal/Rabbit.