Anti-Prostaglandin D2 Synthase (PTGDS)

Anti-Prostaglandin D2 Synthase (PTGDS)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P9053-24B.100 100 µl - -

1 - 19 business days

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that... more
Product information "Anti-Prostaglandin D2 Synthase (PTGDS)"
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease. Applications: Suitable for use in Western Blot . Other applications have not been tested. Recommended Dilution: Western Blot: 2ug/ml , Optimal dilutions to be determined by the researcher. Positive Controls: Human brain lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: P9053-24B


Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to region within residue 1-50 of human PTGDS. [Swiss-Prot# P41222]
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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